![]() Anti–spike protein receptor binding domain IgG titers were determined at baseline and 1 month after enrollment. Screening for SARS-CoV-2 infection was performed every 14 days. The study cohort included 1928 immunocompetent health care workers who were previously vaccinated with a 2-dose series of BNT162b2, and had enrolled between August 8 and 19, 2021, with final follow-up reported through September 20, 2021. ![]() Objective To estimate the association of a BNT162b2 booster dose with SARS-CoV-2 infections among health care workers who were previously vaccinated with a 2-dose series of BNT162b2.ĭesign, Setting, and Participants This was a prospective cohort study conducted at a tertiary medical center in Tel Aviv, Israel. Data are lacking on the effectiveness of booster doses for younger individuals and health care workers. Importance Administration of a BNT162b2 booster dose (Pfizer-BioNTech) to fully vaccinated individuals aged 60 years and older was significantly associated with lower risk of SARS-CoV-2 infection and severe illness.
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June 2023
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